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Method

How we grade evidence, and why the grade sits next to every claim.

One rule governs the whole site: a compound is labelled by the strongest honest tier of evidence that exists for it, never by the strength of the marketing around it.

FDA-approved

FDA-approved

Approved by the FDA with randomised human trial data behind the label.

13 of 51 compounds on this site

Human trials

Human trials

Randomised controlled human trials exist. Not necessarily approved, and not necessarily positive.

11 of 51 compounds on this site

Early human

Early human

Small, uncontrolled, foreign-registry or single-group human studies only.

15 of 51 compounds on this site

Animal-only

Animal-only

Preclinical animal and cell work. No meaningful human evidence.

7 of 51 compounds on this site

Lab-only

Lab-only

Cell culture, theory, or research-reagent status. Not tested in animals for this use, let alone people.

4 of 51 compounds on this site

Harm reported

Harm reported

Used widely without trials, with documented human harm reports.

1 of 51 compounds on this site

What each grade does not mean

Animal-only does not mean it does not work. It means nobody has run the study that would tell you. Those are different statements and conflating them is dishonest in both directions.

FDA-approved does not mean safe for you. It means a specific use, in a specific population, cleared a specific regulatory bar. Semaglutide is approved and still carries a boxed warning.

Human trials does not mean positive trials. Larazotide has better human evidence than almost anything else on this site — a phase 3 that was stopped for futility. AOD-9604 was properly tested for obesity and failed. Both are graded on the quality of the testing, and both entries say plainly what the result was.

Where a claim comes from

Every claim listed on a compound page comes from one of four places: published research, a regulatory document, established clinical practice, or vendor marketing. We list marketed claims deliberately — if people are being sold something for hair loss, the useful response is to show the claim next to the evidence, not to pretend the claim does not exist.

What we will not publish

  • Dose recommendations for unapproved compounds. There is no established human dose for most of them; publishing one would be inventing it.
  • Protocols, cycles or stacks.
  • Vendor links, affiliate links or sourcing advice.
  • A claim we cannot attach to a source.

The calculators are the boundary of what this site does with numbers: they convert quantities you already have. They never originate one.

Corrections

Regulatory status in this field changes several times a year and our entries carry dates for that reason. If something here is out of date or wrong, tell us and we will fix it and note the change.